Chief Investigator: 
Robin Kennedy

Sponsor: University of Oxford & North West London Hospitals NHS Trust
Funded by: Cancer Research UK, Bobby Moore Fund www.cancerresearchuk.org

Conventional versus laparoscopic surgery for colorectal cancer within an enhanced programme.

The aim of the trial is to compare two different approaches to surgery for bowel cancer, within an enhanced recovery programme.

Study Status

Closed to recruitment.
Target recruitment: 202
Total recruitment: 204 patients (May 2012)
Active sites: 11 (May 2012)

Study Schema

Enrol study schema

Inclusion Criteria

  • Diagnosis of colorectal cancer
  • Suitable for elective resection following planned admission
  • >= 18 years of age
  • Written informed consent given

Exclusion Criteria

  • Acute intestinal obstruction
  • Unplanned admission to hospital
  • Unsuitability for epidural insertion - determined pre-randomisation
  • Pregnant
  • Unsuitable for laparoscopic resection as conversion to open surgery is likely

Study Objectives


  • Post-operative physical fatigue


  • Post-operative stay
  • 30 day and in-hospital complications
  • 30 day re-admission & re-operation rates
  • Assessment of health economics using cost-effectiveness & cost utility
  • Patient reported and functional outcomes
  • Cosmetic assessments


EnROL is the first trial run by OCTO that is using web-based submission of data (eCRFs) including randomisation.

Key Dates

Recruitment started: July 2008
End of Recruitment: 18 May 2012
End of Trial: 30 June 2015

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