Reverse the Odds

Reverse The Odds is a fun and unique puzzle adventure game where the further you progress the more you are helping to beat cancer sooner. It is part of a Citizen Science project and has been developed through a partnership between Dr Anne Kiltie of the Department of Oncology, Cancer Research UK and Channel 4.

The Game

Play at your own pace, whether you just have a few minutes waiting for the bus, or hours to kill on the train, you can build a wonderful Odd world and help save lives by improving cancer treatments, sooner.


  • Over 350 levels
  • Meet the Odds. A collection of unique colourful little characters who need your help to return their world to life.
  • Revitalise a desolate wasteland into an amazing wonderland
  • Easy to learn with increasing challenge and difficulty
  • Directly help Cancer Research UK scientists to beat cancer sooner
  • Combine your efforts with a worldwide community of players

By examining the patterns within cancer cell slides and identifying aspects such as the number of cells or the colour of cells, you can move up game levels and achieve rewards.

Don't worry about getting your analysis wrong – the same cell slide data will be studied by many other users to ensure accuracy and no single person's diagnosis or treatment is affected by your actions - your analysis underpins research for future treatments.



The Science

Virtually every cell in the tumour contains a protein called MRE11, but some tumours contain more of this protein than others.  MRE11 is involved in detecting damage to DNA; the same damage caused by radiotherapy, so being able to tell whether different amounts of MRE11 is important for whether radiotherapy works is the next step in this project.

Anne and her group have developed a simple way of detecting the amount of this protein that each cell contains. We could, therefore, test a patient and tell them something about their tumour and how well radiotherapy would work, although we can’t do this until we’re sure that this will be reliable information.

To make sure their idea works, Anne and her group must test and analyse hundreds of patients’ tumours.  This is where they need your help.  Anne has teamed up with Channel 4 and Cancer Research UK to develop a simple game that allows everyone to help analyse the results of their test for MRE11 and other proteins that might also be important.

By playing the game on the bus or in your coffee break, you can help lend a hand to cancer research.  Every person who plays adds to the analysis and speeds up the process of bringing this technology to the clinic where it can benefit cancer patients.

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